Favorite  |  Set Home
Product name : SC66
Item : c2384
Price : 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995
contact : Send inquiry to: info@acesobio.com
CAS : 871361-88-5
Molecular Weight : 276.33
Formula : C18H16N2O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
Description of:SC66
SC66(cas: 871361-88-5 )is a novel Akt inhibitor, reduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells.
SC66 treatment led to a reduction in total and phospho-AKT levels. SC66 significantly potentiated the effects of both conventional chemotherapeutic and targeted agents, doxorubicin and everolimus, respectively. In vivo, SC66 inhibited tumor growth of Hep3B cells in xenograft models, with a similar mechanism observed in the in vitro model.

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data. 

REFERENCES


1: Cusimano A, Puleio R, D'Alessandro N, Loria GR, McCubrey JA, Montalto G, Cervello M. Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells. Oncotarget. 2015 Jan 30;6(3):1707-22. PubMed PMID: 25596737.

2: Tran HT, Zhang S. Accurate prediction of the bound form of the Akt pleckstrin homology domain using normal mode analysis to explore structural flexibility. J Chem Inf Model. 2011 Sep 26;51(9):2352-60. doi: 10.1021/ci2001742. Epub 2011 Aug 25. PubMed PMID: 21834588; PubMed Central PMCID: PMC3807676.

3: Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6486-91. doi: 10.1073/pnas.1019062108. Epub 2011 Apr 4. PubMed PMID: 21464312; PubMed Central PMCID: PMC3081014.


Related Products :
AT 7867
AT 7867
Price: 200mg, $750;500mg, $1250; 1g $1950; 2g, $3050
PHT 427
PHT 427
Price: 200mg, $649;500mg, $1050; 1g $1595; 2g, $2355
GSK 690693
GSK 690693
Price: 200mg, $750;500mg, $1250; 1g $1950; 2g, $3050
Triciribine
Triciribine
Price: 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
GDC 0068
GDC 0068
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
Perifosine (KRX-0401)
Perifosine (KRX-0401)
Price: 200mg, $449;500mg, $850; 1g $1195; 2g, $1795
Isobavachalcone
Isobavachalcone
Price: 200mg, $649;500mg, $1050; 1g $1595; 2g, $2355
BX 795
BX 795
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590