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Product name : PHT 427
Item : cc348
Price : 200mg, $649;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : We offer significant discount for larger quantity order
Molecular Weight : 409.61
Formula : C₂₀H₃₁N₃O₂S₂
Storage : 1191951-57-1
Additional information : We offer significant discount for larger quantity order
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Details:
PHT427 is an AKT inhibitor that inhibits AKT and PDPK1 at low micromolar concentrations in numerous cancer cell lines and exhibits good oral anti-tumor activity in mouse xenograft models.  PHT-427 reduces the phosphorylation of AKT and PDPK1. Following the administration of a single oral dose of PHT427 to mice bearing BxPC-3 human pancreatic tumor xenografts, PHT-427 inhibited the phosphorylation of both Akt and PDPK1 as well as downstream targets maximally at 8–12 h after administration corresponding to its peak plasma concentration, with PDPK1 inhibition extending to 24 hr. [1][2]
  
Reference:
[1] Mol. Cancer Ther. 2010, 9, 706-717.
[2] Cancer Res. 2009, 69, 5073-5081.
 
 
Chemical Information
Molecular Weight (WM):
409.61
Formula:
C20H31N3O2S2
CAS No:
1191951-57-1
Purity:
≥ 98%
Synonyms:
PHT-427
 
DMSO ≥ 82 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 82 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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