Favorite  |  Set Home
Products > PI3K/Akt/mTOR > PI3K > Acalisib (Synonyms: GS-9820; CAL-120)
Product name : Acalisib (Synonyms: GS-9820; CAL-120)
Item : c2351
Price : 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com
CAS : 870281-34-8
Molecular Weight : 401.4
Formula : C21H16FN7O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
 Enlarge Image                   Back
             [Next Product]→


Details:
Description of:Acalisib (Synonyms: GS-9820; CAL-120)
Acalisib(CAS:870281-34-8) is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM.p110beta/delta PI3K inhibitor GS-9820 inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells.

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data. 

REFERENCES

[1]. Shugg RP, et al. Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption. J Biol Chem. 2013 Dec 6;288(49):35346-57.
[2]. Lopez-Guadamillas E, et al. PI3Kα inhibition reduces obesity in mice. Aging (Albany NY). 2016 Nov 4;8(11):2747-2753.


Related Products :
NVP-BKM120 (BKM 120)
NVP-BKM120 (BKM 120)
Price: 2g, $650;5g, $1050; 10g $1650
AZD 6482
AZD 6482
Price: 200mg, $750;500mg, $1250; 1g $1950; 2g, $3050
ZSTK 474
ZSTK 474
Price: 200mg, $850;500mg, $1450; 1g $2250; 2g, $3350
PKI 587 (PF-05212384)
PKI 587 (PF-05212384)
Price: 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
NVP-BEZ235 (BEZ 235)
NVP-BEZ235 (BEZ 235)
Price: 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
PKI 402
PKI 402
Price: 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
GDC-0077
GDC-0077
Price: 200mg, $1750;500mg, $2890; 1g, $3950;
PP 121
PP 121
Price: 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450