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Product name : AMG 208
Item : cc218
Price : 10mg, $275; 50mg, $765; 100mg, $1295; 200mg, $2195
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
AMG-208 is a highly selective c-Met inhibitor with IC50 of 9.3 nM. AMG208 inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity, which may result in cell growth inhibition in tumors that overexpress c-Met. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers.   [1][2]
 
Reference:
[1] J Med. Chem. 2008, 51, 2879-2882.
[2] Bioorg. Med. Chem. Lett. 2009, 19, 6307-6312.
 
 
Chemical Information
Molecular Weight (WM):
383.40
Formula:
C22H17N5O2
CAS No:
1002304-34-8
Purity:
≥ 98%
Synonyms:
AMG 208
 
DMSO < 1 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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