Favorite  |  Set Home
Products > Receptor Tyrosine Kinase > VEGFR > Brivanib alaninate (BMS-582664)
Product name : Brivanib alaninate (BMS-582664)
Item : cc420
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 649735-63-7
Molecular Weight : 441.46
Formula : C₂₂H₂₄FN₅O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
Brivanib alaninate (BMS-582664) is VEGFR-PDGFR inhibitor. Brivanib alaninate is a multiple inhibitor of VEGFR( IC50 of VEGFR-2(25 nM), VEGFR-1 (380nM), VEGFR-3 (10 nM)); FGFR (FGFR-1 (IC50=148 nM), FGFR-2 (IC50 =125 nM), and FGFR-3 (IC50 = 68 nM))tyrosine kinases. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression.   [1][2]
 
Reference:
[1] Clin. Cancer Res. 2008, 14, 6146-6153.
[2] J Med. Chem. 2008, 51, 1976-1980.
 
 
Chemical Information
Molecular Weight (WM):
441.46
Formula:
C22H24FN5O4
CAS No:
649735-63-7
Purity:
≥ 98%
Synonyms:
BMS582664, BMS 582664
 
DMSO ≥ 88 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 88 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

Related Products :
Vandetanib (Zactima, ZD 6474)
Vandetanib (Zactima, ZD 6474)
Price: 2g, $650;5g, $1050; 10g $1650
ZM 306416
ZM 306416
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
Telatinib (BAY 57-9352)
Telatinib (BAY 57-9352)
Price: 10mg, $225; 50mg, $795; 100mg, $1295; 200mg, $2195
R1530
R1530
Price: 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
Cabozantinib (XL-184)
Cabozantinib (XL-184)
Price: 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
E7080 (Lenvatinib)
E7080 (Lenvatinib)
Price: 2g, $650;5g, $1050; 10g $1650
ABT-869 (Linifanib, AL 39324)
ABT-869 (Linifanib, AL 39324)
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
RAF 265 (CHIR 265)
RAF 265 (CHIR 265)
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355