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Products > Receptor Tyrosine Kinase > VEGFR > Brivanib alaninate (BMS-582664)
Product name : Brivanib alaninate (BMS-582664)
Item : cc420
Price : 10mg, $375; 50mg, $825; 100mg, $1195;200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Brivanib alaninate (BMS-582664) is VEGFR-PDGFR inhibitor. Brivanib alaninate is a multiple inhibitor of VEGFR( IC50 of VEGFR-2(25 nM), VEGFR-1 (380nM), VEGFR-3 (10 nM)); FGFR (FGFR-1 (IC50=148 nM), FGFR-2 (IC50 =125 nM), and FGFR-3 (IC50 = 68 nM))tyrosine kinases. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression.   [1][2]
 
Reference:
[1] Clin. Cancer Res. 2008, 14, 6146-6153.
[2] J Med. Chem. 2008, 51, 1976-1980.
 
 
Chemical Information
Molecular Weight (WM):
441.46
Formula:
C22H24FN5O4
CAS No:
649735-63-7
Purity:
≥ 98%
Synonyms:
BMS582664, BMS 582664
 
DMSO ≥ 88 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 88 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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