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Products > Receptor Tyrosine Kinase > VEGFR > Telatinib (BAY 57-9352)
Product name : Telatinib (BAY 57-9352)
Item : cc418
Price : 10mg, $225; 50mg, $795; 100mg, $1295; 200mg, $2195
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Telatinib (BAY 57-9352) is a potent inhibitor of VEGFR-2, VEGFR-3, c-Kit and PGFR-β with IC50 of 6 nM, 4 nM, 1 nM and 15 nM, respectively. Telatinib binds to and inhibits the vascular endothelial growth factor receptors (VEGFRs) type 2 and 3, platelet-derived growth factor receptor beta (PDGFRb) and c-Kit, which may result in the inhibition of angiogenesis and cellular proliferation in tumors in which these receptors are upregulated. These telatinib-inhibited receptor protein tyrosine kinases are overexpressed or mutated in many tumor cell types and may play key roles in tumor angiogenesis and tumor cell proliferation. 17-AAG is a synthetic analogue of the benzoquinone ansamycin antibiotic geldanamycin and has also been found to inhibit the molecular chaperone Hsp90.  [1][2]
 
 
 
 
Reference:
[1] Clin. Cancer Res. 2008, 14, 3470-3476.
[2] Br. J Cancer 2008, 99, 1579-1585.
 
 
 
 
Chemical Information
Molecular Weight (WM):
309.83
Formula:
C20H26ClN5O3
CAS No:
332012-40-5
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 82 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 1 mg/mL
 
2 years     -20        Powder
Stability:
2 weeks     -4        in DMSO
 
2 months    -80       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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