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Products > MAPK > MEK > GSK 1120212 (Trametinib, JPT 74)
Product name : GSK 1120212 (Trametinib, JPT 74)
Item : cc-37
Price : 10mg,$110; 50mg, $475; 100mg, $695; 200mg, $ 995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
GSK 1120212 (Tranmetinib) is a reversible, selective, allosteric MEK1/MEK2 kinase activity inhibitor with IC50 of 0.7 nM and 0.9 nM for MEK1 and MEK2. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. [1][2]
Reference:
[1] Int. J Oncol. 2011, 39, 23-32.
[2] Curr. Oncol. Rep. 2010, 12, 146-152.
                                        
Chemical Information
Molecular Weight (WM):
615.39
Formula:
C26H23FIN5O4
CAS No:
871700-17-3
Purity:
≥ 98%
Synonyms:
GSK212, Trametinib, JPT 74057,
 
DMSO ≥ 6 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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