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Product name : NVP-BSK805
Item : cc625
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1092499-93-8
Molecular Weight : 490.55
Formula : C₂₇H₂₈F₂N₆O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with an IC50 with 0.5 nM. Within the JAK family, NVP-BSK805 displays more than 20-fold selectivity towards JAK2 in vitro, as well as excellent selectivity in broader kinase profiling. The compound blunts constitutive STAT5 phosphorylation in JAK2(V617F)-bearing cells, with concomitant suppression of cell proliferation and induction of apoptosis.     [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2010, 9, 1945-1955.
[2] BMC Cancer 2011, 11, 24.
 
 
Chemical Information
Molecular Weight (WM):
563.47
Formula:
C27H28F2N6O.2HCl
CAS No:
1092499-93-8 (free base)
Purity:
≥ 98%
Synonyms:
BSK 805
 
DMSO ≥ 113 mg/mL
Solubility (25℃)
Water ≥ 8 mg/mL
 
Ethanol ≥ 17 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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