Favorite  |  Set Home
Products > Others > > CCT007093
Product name : CCT007093
Item : CR1790
Price : 200mg, $845; 500mg, $1485
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 176957-55-4
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
 Chemical Information
M.Wt 272.39 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C15H12OS2
CAS No 176957-55-4
Solubility

DMSO > 3 mg/ml



Biological Activity of CCT007093

 

CCT 007093is an effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines.
IC50 value:
Target: PPM1D
As expected of a specific inhibitor, the toxicity of CCT007093 to PPM1D overexpressing cell lines after inhibitor treatment is P38 dependent [1]. Knockdown of WIP1 or treatment with the WIP1 inhibitor CCT007093 results in increased phosphorylation of known WIP1 targets, reduced HDM2 expression, and reduced growth specifically in WIP1 wild-type and high-expressing medulloblastoma cells [2]. CCT007093 treatment appeared to promote apoptosis in breast cancer cells and skin transformed keratinocytes that ectopically expressed Wip1, demonstrating that the effect of CCT007093 differs based on the level of Wip1 expression [3].

 

[1]. Rayter S, et al. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene. 2008 Feb 14;27(8):1036-44.
[2]. Buss MC, et al. HDM2 promotes WIP1-mediated medulloblastoma growth. Neuro Oncol. 2012 Apr;14(4):440-58.
[3]. Lee JS, et al. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014 Feb;73(2):125-34.


Related Products :
Retapamulin (SB 275833)
Retapamulin (SB 275833)
Price: 10mg, $125; 50mg, $495; 100mg, $995; 200mg, $1695
SB 705498
SB 705498
Price: 10mg, $195; 50mg, $795; 100mg,$1295; 200mg, $2155
AN2728
AN2728
Price: 200mg, $845; 500mg, $1485
ZLN005
ZLN005
Price: 500mg, $945; 1g, $1485
CK-636
CK-636
Price: 200mg, $845; 500mg, $1485
Ramelteon (TAK 375, Rozerem)
Ramelteon (TAK 375, Rozerem)
Price: 10mg, $325; 50mg,$1175; 100mg, $1695; 200mg,$2475
HS-173
HS-173
Price: 200mg, $945;500mg, $1485
Y320
Y320
Price: 100mg, $845; 200mg, $1285