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Product name : NVP-BHG712
Item : cc540
Price : 10mg, $275; 50mg, $725; 100mg, $1295; 200mg, $2295
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Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7μM, respectively.  EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. In addition, several reports suggest that this receptor ligand pair is also involved in pathologic vessel formation in adults including tumor angiogenesis. NVP-BHG712, which inhibits EphB4 kinase activity in the low nanomolar range in cellular assays showed high selectivity for targeting the EphB4 kinase. Furthermore, NVP-BHG712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral administration.  [1][2]
 
Reference:
[1] Angiogenesis 2010, 13, 259-267.
[2] Kidney Int. 2012, 81, 1212-1225.

 
Chemical Information
Molecular Weight (WM):
503.48
Formula:
C26H20F3N7O
CAS No:
940310-85-0
Purity:
≥ 98%
Synonyms:
BHG-712, BHG712
 
DMSO ≥ 101 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 37 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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