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Product name : LGX-818
Item : CR1865
Price : 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com
CAS : 1269440-17-6
Molecular Weight : 540.01
Formula : C₂₂H₂₇ClFN₇O₄S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
 Chemical Information
M.Wt 540.01 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C22H27ClFN7O4S
CAS No 1269440-17-6
Solubility

DMSO



Biological Activity of LGX818

 

LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.
IC50 value: 0.3 nM (BRaf V600E biochemical); 2 nM (A375 cell proliferation) [1]
Target: mutated BRaf V600E
LGX818 is a drug candidate for the treatment of melanoma with the V600E mutation in the B-RAF kinase. The substance is being developed by Novartis, is in phase III clinical trials, and was disclosed at the spring 2013 American Chemical Society meeting in New Orleans. More information can be found in Patent WO2011025927A1

 

 

[1]. Compounds and compositions as protein kinase inhibitors . Patent WO 2011025927 A1

[2]. LGX818, From Wikipedia, the free encyclopedia


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