Favorite  |  Set Home
Products > MAPK > Raf > LGX-818
Product name : LGX-818
Item : CR1865
Price : 50mg, $2945; 100mg, $4450
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1269440-17-6
 Enlarge Image                   Back
             [Next Product]→


Details:
 Chemical Information
M.Wt 540.01 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C22H27ClFN7O4S
CAS No 1269440-17-6
Solubility

DMSO



Biological Activity of LGX818

 

LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.
IC50 value: 0.3 nM (BRaf V600E biochemical); 2 nM (A375 cell proliferation) [1]
Target: mutated BRaf V600E
LGX818 is a drug candidate for the treatment of melanoma with the V600E mutation in the B-RAF kinase. The substance is being developed by Novartis, is in phase III clinical trials, and was disclosed at the spring 2013 American Chemical Society meeting in New Orleans. More information can be found in Patent WO2011025927A1

 

 

[1]. Compounds and compositions as protein kinase inhibitors . Patent WO 2011025927 A1

[2]. LGX818, From Wikipedia, the free encyclopedia


Related Products :
AZ 628
AZ 628
Price: 10mg, $195; 50mg, $595; 100mg, $995; 200mg, $1455
PLX 4720
PLX 4720
Price: 10mg/$120; 25mg/$195; 50mg/$450, 100mg/$595
GW 5074
GW 5074
Price: 5mg, $110; 50mg, $175; 150mg, $345
PLX 4032 (RG 7204, Zelboraf, RO 5185426)
PLX 4032 (RG 7204, Zelboraf, RO 5185426)
Price: 10mg, $60; 50mg, $245; 100mg, $450; 200mg; $695
NVP-BHG712
NVP-BHG712
Price: 10mg, $275; 50mg, $725; 100mg, $1295; 200mg, $2295
ZM 336372
ZM 336372
Price: 10mg, $95, 50mg, $295; 100mg, $545; 200mg, $995
SB 590885 (GSK 2118436, Dabrafenib)
SB 590885 (GSK 2118436, Dabrafenib)
Price: 10mg, $145; 50mg, $575; 100mg, $875; 200mg, $1595
GDC 0879
GDC 0879
Price: 10mg, $145; 50mg, $455; 100mg, $745; 200mg, $995