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Products > Cell Cycle > CDK > Roscovitine (Seliciclib, CYC 202, R-roscovitine)
Product name : Roscovitine (Seliciclib, CYC 202, R-roscovitine)
Item : cc362
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 186692-46-6
Molecular Weight : 354.45
Formula : C₁₉H₂₆N₆O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective inhibitor of the cyclin-dependent kinases with IC50 of 0.65, 0.7, 0.7 and 0.16 μM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E and cdk5/p53, respectively. Seliciclib primarily inhibits CDK2/E, CDK2/A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, inhibiting RNA polymerase II-dependent transcription, which may result in the down-regulation of antiapoptotic proteins such as induced myeloid leukemia cell differentiation protein Mcl-1. CDKs, serine/threonine kinases that play an important role in cell cycle regulation, are overexpressed in various malignancies. Mcl-1 belongs to the Bcl-2 family of antiapoptotic proteins and is a protein crucial to the survival of a range of tumor cell types. [1][2]
 
Reference:
[1] J Biol. Chem. 1997, 243, 527-536.
[2] J Clin. Invest. 1997, 100, 2512-2520.
 
 
Chemical Information
Molecular Weight (WM):
354.45
Formula:
C19H26N6O
CAS No:
186692-46-6
Purity:
≥ 98%
Synonyms:
CYC-202
 
DMSO ≥ 71 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 71 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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