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Product name : PD 0332991
Item : cc424
Price : 10mg, $125; 50mg, $495; 100mg, $695; 200mg, $1095
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
PD0332991 is a highly selective inhibitor of Cdk4/cyclin D1 and Cdk6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively. PD-0332991 selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation; inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation.  [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2004, 3, 1427-1438.
[2] Cancer Res. 2008, 68, 5519-5523.
 
 
Chemical Information
Molecular Weight (WM):
483.99
Formula:
C24H29N7O2.HCl
CAS No:
827022-32-2, 571190-30-2 (free base)
Purity:
≥ 98%
Synonyms:
PD 0332991
 
DMSO ≥ 25 mg/mL
Solubility (25℃)
Water ≥ 90 mg/mL
 
Ethanol ≥ 5 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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