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Product name : ZM 447439
Item : cc-90
Price : 10mg, $95, 50mg, $395; 100mg, $695; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
ZM-447439 is a potent and selective inhibitor of Aurora B kinase (IC50=50nM), Aurora A and C are inhibited at higher concentrations (IC50=1000nM and 250nM respectively). Other kinases such as Cdk1 and PLK1 are not inhibited (up to 10mM). Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. [1][2]
 
Reference:
[1] Haematologica 2008, 93, 662-669.
[2] Cell Cycle. 2008, 7, 1473-1479.
 
 
Chemical Information
Molecular Weight (WM):
513.59
Formula:
C29H31N5O4
CAS No:
331771-20-1
Purity:
≥ 98%
Synonyms:
ZM447439, ZM-447439
 
DMSO ≥ 103 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 48 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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