Apoptosis
KSp
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Product name : Barasertib (AZD1152-HQPA)
Item : cc-48
Price : 200mg, $850;500mg, $1650; 1g $2250; 2g, $3450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 722544-51-6
Molecular Weight : 507.56
Formula : C₂₆H₃₀FN₇O₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Barasertib (AZD1152-HQPA) is an orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase B inhibitor AZD1152–hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with a Ki of 0.36 nM. Barasertib inhibits Aurora A with a Ki of 1.37 nM. Upon administration and rapid conversion from the prodrug form in plasma, barasertib specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. Consequently, cell division and cell proliferation are inhibited and apoptosis is induced in Aurora kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase that functions in the attachment of the mitotic spindle to the centromere, is overexpressed in a wide variety of cancer cell types. [1][2]
Reference:
[1] Blood, 2011, 118, 6030-6036.
[2] Leuk. Res. 2011, 35, 1384-1389.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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