ONX 0914 (PR 957)

ONX-0914 (PR-957) is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflam...

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Oprozomib (ONX 0912)

Oprozomib(ONX-0912) is an orally bioavailable proteasome inhibitor with potential antineoplastic activity. ONX0912 inhibits the activity of the protea...

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Ganetespib (STA 9090)

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells. Ganetespib binds to and inhibits Hsp90, resulting in the proteasomal deg...

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PSI 7977

PSI-7977 is an investigational nucleotide analog currently in Phase 2 for treatment of chronic HCV infection. PSI-7851 is a mixture of two similar mol...

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PSI 6130

PSI-6206 is an effective inhibitor of hepatitis C virus (HCV) replication in vitro. [1][2] &nbs...

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Carfilzomib (PR 171)

Carfilzomib (PR-171) is a proteasome inhibitor with IC50 less than 5 nM. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity...

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Lopinavir (ABT 378)

Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class. ABT378 acts aAs a component of combination therapy to treat HIV/AIDS. Inhibi...

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Indinavir

Indinavir (Crixivan) is a protease inhibitor used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and AIDS. [1]I...

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BMS232632 (Atazanavir, Reyataz)

BMS232632 (Atazanavir, Reyataz) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, BMS-232632 is used to trea...

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Alogliptin (SYR 322)

Alogliptin (SYR-322) is an orally administered, anti-diabetic drug in the DPP-4 inhibitor class. [1][2] Reference: [1] J Med. Chem. 2007, 50...

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KW 2478

KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action rema...

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Danoprevir

Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with an IC50 of 0.2-3.5 nM.Preclinical data demonstrated th...

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Geldanamycin

Geldanamycin is a natural existing Hsp90 inhibitor with Kd with 1.2 μM or 0.78 μM while binding to full-length dimeric Hsp90 or the N-terminal d...

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NVP-BEP800 (VER 82576)

NVP-BEP800 (VER-82576) is a novel, fully synthetic, oral Hsp90β inhibitor with IC50 of 58 nM. NVP-BEP800 potently inhibits the proliferation of v...

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NVP-AUY922 (AUY 922, VER 52296)

NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor to HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively. AUY922 has been ...

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SNX 2112

SNX-2112 selectively binds to the ATP pocket of Hsp90 family members Hsp90α and Hsp90β with Ka of 30 nM and 30 nM, respectively. In all cel...

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