SRT 1720

SRT-1720 is a selective human silent information regulator 1 (SIRT1) activator with EC1.5 of 0.16 μM. This agent binds to the SIRT1 enzyme-peptide ...

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SR 48692

SR-48692 is a drug which acts as a selective, non-peptide antagonist at the neurotensin receptor NTS1, and was the first non-peptide antagonist develo...

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Retapamulin (SB 275833)

Retapamulin (SB-275833) is an antibacterial agent, specifically a protein synthesis inhibitor. The medication selectively inhibits bacterial protein s...

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SB 705498

SB705498 is a TRPV1 antagonist for hTRPV1 with pIC50 and pKi of 7.1 and 7.6 in HEK293 cells. Vanilloid receptor-1 (TRPV1) is a nonselective cati...

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Ramelteon (TAK 375, Rozerem)

Ramelteon (TAK-375, Rozerem) showed very high affinity for human MT1 (Mel1a) and MT2 (Mel1b) receptors and chick forebrain melatonin receptors with Ki...

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Ezetimib

Ezetimibe (Zetia) localises at the brush border of the small intestine, where it inhibits the absorption of cholesterol from the intestine. Specifical...

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Argatroban

Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. [1][2] Reference: [1] Eng. J Med. 2005, 353, 1028-1040. ...

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SL 251188

SL-251188, an oxazolidinone derivative, was characterized in baboons as a radioligand for the in vivo visualization of MAO-B using positron emission t...

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ICG 001

CG-001 is a selective Wnt/β-catenin signalling inhibitor with an IC50 of 3μM. ICG 001, a small molecule that down-regulates beta-catenin/T cel...

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PF 670462

PF 670462 acts as a potent and reversible inhibitor of casein kinase Iε/δ (IC50 = 7.7 and 14 nM, respectively) with modest to excellent ...

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GSK 1210151A (I-BET151)

I-BET151 (GSK1210151A) is a novel and selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4 with IC50 o...

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LY 2886721

LY2886721 is a novel potent agent that is used to treat Alzheimer’s Disease in preclinical experiments. LY2886721 is under clinical study. A Saf...

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Darbufelone

Darbufelone was discovered as a dual inhibitor of cellular prostaglandin and leukotriene production. Darbufleone potently inhibits PGHS-2 with IC50 of...

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Fidarestat

Fidarestat (SNK-860) is an aldose reductase inhibitor. Long-term treatment with SNK-860 has a beneficial preventive effect on the development of exper...

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Marbofloxacin

Marbofloxacin (Marbocyl, Zeniquin) is a potent antibiotic inhibiting bacterial DNA replication.Marbofloxacin is a potent antibiotic of the 3rd generat...

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Safinamide (FCE28073)

Safinamide (EMD 1195686; FCE 26743; ) is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopam...

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