|
|
Rocilinostat (ACY 1215)
Rocilinostat, also known as ACY1215, is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic...
More>>
|
|
|
|
EX 527
Mammalian sirtuin 1 (SIR1) is a dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX 527 is a cell-p...
More>>
|
|
|
|
Resminostat (4SC-201)
Resminostat (4SC-201) is an orally administered histone deacetylase (HDAC) inhibitor for the treatment of cancers, which modifies the DNA structure of...
More>>
|
|
|
|
|
|
Cytarabine (Cytosine)
Cytarabine (Cytosine) is an antimetabolic agent and DNA synthesis inhibitor with an IC50 of 16 nM in wild-type CCRF-CEM cells. [1][2]
Referen...
More>>
|
|
|
|
Troxacitabine
Troxacitabine (Troxatyl) is a nucleoside analogue with anticancer activity. Its use is being studied in patients with refractory lymphoproliferative d...
More>>
|
|
|
|
MS 275 (SNDX 275)
MS-275 (SNDX-275) is a HDAC inhibitor of HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively. MS275 (SNDX275) binds to and inhibits hi...
More>>
|
|
|
|
NSC 696085 (Pyroxamide)
NSC-696085(Pyroxamide) inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin struct...
More>>
|
|
|
|
|
|
MC 1568
MC1568 is a class II (IIa) selective HDAC inhibitor with IC50 of 220 nM. MC-1568 exhibits tissue-selective inhibition between members of class II acet...
More>>
|
|
|
|
Nelarabine (Arranon)
Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor for HSB2 cell lines and ALL-SIL cell lines with IC50 of 0.13 &m...
More>>
|
|
|
|
Clofarabine
Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucle...
More>>
|
|
|
|
Exatecan
Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of ...
More>>
|
|
|
|
CX 5461
CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM. Deregulated ribosomal RNA synthesis is associated with uncontr...
More>>
|
|
|
|
Trichostatin A (TSA)
Trichostatin A (TSA) is a potent, reversible inhibitor of histone deacetylase (HDAC). In human Jurkat T cells, trichostatin A arrests cell cycle progr...
More>>
|
|
|
|
Droxinostat (NS 41080)
Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8. Droxinostat shows comparable inhibition of HDAC6 and HDAC8 (IC50 = 2.47 and 1.46 μ...
More>>
|
|
Apoptosis
DHFR
Chinese
Deutsch
Espanol
Francais
Italiano
Portugues
Japanese
Korean
Arabic
Russian