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Product name : CAL101
Item : cc41
Price : 2g, $650;5g, $1050; 10g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 870281-82-6
Molecular Weight : 415.42
Formula : C₂₂H₁₈FN₇O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
CAL-101 (GS 1101) is a potent PI3K p110δ inhibitor with an IC50 of 65 nM. PI3K-delta inhibitor CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. [1][2]
 
Reference:
[1] Blood 2011, 117, 591-594.
[2] Blood, 2010, 116, 2078-2088.
 
 
Chemical Information
Molecular Weight (WM):
415.42
Formula:
C22H18FN7O
CAS No:
870281-82-6
Purity:
≥ 98%
Synonyms:
CAL-101, CAL 101, GS1101, GS-1101
 
DMSO ≥ 83 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 35 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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