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Product name : TAK 733
Item : cc621
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1035555-63-5
Molecular Weight : 504.23
Formula : C₁₇H₁₅F₂IN₄O₄
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
TAK-733 is a potent, selective, ATP-noncompetitive MEK allosteric site inhibitor with an IC50 of 3.2 nM. TAK733 selectively binds to and inhibits the activity of MEK1/2. TAK 733 prevents the activation of MEK1/2-dependent effector proteins and transcription factors, which mayresult in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.   [1][2]
 
Reference:
[1] Bioorg. Med. Chem. Lett. 2011, 21, 1315-1319.
[2] Mol. Cancer 2012, 11, 22.
 
 
Chemical Information
Molecular Weight (WM):
504.23
Formula:
C17H15F2IN4O4
CAS No:
1035555-63-5
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 191 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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