Epothilone B (EPO906) is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. patupilone induces microtubule polymerization and stabil...

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Epothilone A

Epothilone A is a Taxol-like microtubule-stabilizing agent with EC0.01 of 2 μM. Epothilone A binds to tubulin and induces microtubule polymerizatio...

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TAK 960

TAK-960 is a novel, potent and selective PLK1 inhibitor with IC50 of 8 nM. TAK960 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest...

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GSK 461364

GSK461364 is a thiophene amide that inhibits purified Plk1 enzyme with Ki of 2 nM. GSK-461364 selectively inhibits Plk1, inducing selective G2/M...

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BI 6727 (Volasertib)

BI6727 (Volasertib) is a highly potent Polo-like kinase 1 (Plk1) inhibitor with IC50 of 0.87 nM.PLK1 proteins are found in the nuclei of all dividing ...

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ON 01910

ON-01910 (Estybon, Novonex, Rigosertib) is a non-ATP-competitive inhibitor to Polo-like kinase 1 (PLK1) with IC50 of 9 nM. ON01910 blocks certain prot...

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BI 2536

BI-2536 is a potent polo-like kinase 1 (Plk1) inhibitor with IC50 of 0.83 nM. BI2536 blocks the activities of Plk2 and Plk3 to a slightly lesser exten...

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GW 8248

GW678248 is a novel reverse transcriptase inhibitor (NNRTI). Preclinical assessment of GW-678248 indicates that this compound potently inhibits wild-t...

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Combretastatin A4

Combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cel...

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PF 00477736 (PF 477736)

PF-00477736 (PF-477736) is a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49 nM. PF00477736 (PF477736)...

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PHA 767491

PHA-767491 is a potent ATP-competitive dual Cdc7/Cdk9 inhibitor with IC50 of 10 nM and 34 nM, respectively. PHA767491 prevents initiation of DNA repli...

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CCT 241533

CCT241533 blocked CHK2 activity in human tumor cell lines in response to DNA damage. CHK2 is a checkpoint kinase involved in the ATM-mediated response...

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Fasudil

Fasudil HCl is cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor with an IC50 of 10.7 μM. It is also a Ca2+ ...

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PD 0332991

PD0332991 is a highly selective inhibitor of Cdk4/cyclin D1 and Cdk6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively. PD-0332991 selectively inhi...

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Abacavir

Abacavir is a nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS. [1][2] Reference: [1] A...

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Rilpivirine (TMC 278)

Rilpivirine (TMC278) is developed for the treatment of HIV infection. Rilpivirine is a second-generation non-nucleoside reverse transcriptase inhibito...

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