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Product name : PP 121
Item : cc496
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1092788-83-4
Molecular Weight : 319.36
Formula : C₁₇H₁₇N₇
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
PP 121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). PP-121 exhibits no significant effect on receptor serine/threonine kinases (RSTKs). PP 121 blocks the proliferation of tumor cells by direct inhibition of PI3-K, mTOR, Src and the VEGF receptor. PP121 potently and dose-dependently blocked the phosphorylation of Akt, p70S6K and S6 in these cells. [1]
 
Reference:
[1] Nature Chem. Biol. 2008, 4, 691-699.
 
 
Chemical Information
Molecular Weight (WM):
319.37
Formula:
C17H17N7
CAS No:
1092788-83-4
Purity:
≥ 98%
Synonyms:
PP121, PP-121
 
DMSO ≥ 64 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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