GSK 2636771

GSK 2636771 is a potent, orally bioavailable, PI3K beta-selective inhibitor, currently in Phase I/II trials. [1] Reference:...

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AZD 2014

AZD2014 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a s...

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OSU 03012 (N/NAAR-12)

OSU-03012 is a recently licensed novel derivative of the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CelebrexTM). However, OSU03012 lacks COX-2 inhi...

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Perifosine (KRX-0401)

Perifosine (KRX0401) modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resultin...

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Palomid 529 (P529)

Palomid 529 (P529), which inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and ...

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CCT 128930

CCT128930 is a novel ATP-competitive AKT inhibitor discovered using fragment- and structure-based approaches. It is a potent, advanced lead pyrrolopyr...

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A 674563

A-674563 is a potent selective protein kinase B/Akt inhibitor with an IC50 of 14 nM. A674563 also shows inhibitory activity against PKA and CDK2 with ...

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Isobavachalcone

Isobavachalcone (IBC), a natural chalcone, potently abrogates Akt signaling and exerts anti-proliferative effects on several human cancer cell lines. ...

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PHT 427

PHT427 is an AKT inhibitor that inhibits AKT and PDPK1 at low micromolar concentrations in numerous cancer cell lines and exhibits good oral anti-tumo...

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TWS 119

TWS 119 is a cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC50 = 30 nM). TWS119 binds to GSK-3β with...

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SB 216763

SB 216763 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM for GSK-3α); competes with ATP. SB 216763 has minima...

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CHIR 99021 (CT99021)

CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3β (GSK3β) reported to date. CHIR-99021 (CT99021) has antiproliferativ...

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CP 466722

CP 466722 is rapidly reversible potential ATM kinase inhibitor. CP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family me...

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KU 57788 (NU 7441)

NU 7441(KU 57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 values are 14, 1700, 5000, >100000 and >100000...

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KU 55933

KU 55933 is a potent, selective and competitive ATM kinase inhibitor (Ki = 2.2 nM, IC50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 ...

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Ku 60019

KU 60019 is a potent and specific ATM kinase inhibitor with IC50 of 6.3 nM. Compared to KU-55933, KU-60019 is an improved more water-soluble inhibitor...

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