GSK 690693

GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3 with IC50 values of 1, 13, 9 nM respectively, which may result in the inhibition of protein p...

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AT 7867

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. This ATP-competitive...

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MK 2206

MK 2206 is an Akt inhibitor, is also an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with po...

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Torin 1

Torin 1 is a potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin 1 displays 200-fold selectivity for mTOR over DNA-PK,...

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Torin 2

Torin 2 is an orally available, potent and selective mTOR inhibitor with an IC50 of 2.1nM. It displays 800 fold cellular selectivity for mTOR over PI3...

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GDC 0980 (RG7422)

GDC 0980 (RG7442) shows the potent and selective inhibitory activities against class I PI3K and mTOR kinase versus a large panel of kinases with Ki of...

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NVP-BGT226 (BGT 226)

NVP-BGT226 is a novel, orally bioavailable small-molecule inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin. NVP-BGT226 inhibits...

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KU 0063794

Ku-0063794, inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or sev...

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Temsirolimus (Torisel)

Temsirolimus (CCI-779) is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival...

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WYE 354

WYE 354 is a cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP-competitive mTOR inhibitor (IC50 = 5 nM with S6K as the substrat...

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PP 242

PP 242 is a potent and selective mTOR inhibitor. PP242 is a first selective inhibitor that targets ATP domain of mTOR. PP242 targets the ATP dom...

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Rapamycin (Sirolimus)

Rapamycin (Sirolimus)binds the cytosolic protein FK-binding protein 12 (FKBP12) in a manner similar to tacrolimus. The sirolimus-FKBP12 complex inhibi...

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Everolimus (RAD001)

Everolimus (RAD001) is a type of targeted therapy that blocks mTOR, a protein in cells that normally promotes their growth and division. By blocking t...

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NVP-BEZ235 (BEZ 235)

NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the effi...

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ZSTK 474

ZSTK474 is an inhibitor of PI3K γ (IC50 at 6 nM). This agent inhibits PI3K α and PI3K β with IC50 of 17 and 53 nM, respectively. West...

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NVP-BKM120 (BKM 120)

NVP-BKM120 efficiently blocks constitutive activation of PI3K/AKT pathway in FL cells, and completely abrogates AKT activation derived from co-culture...

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