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AST 1306(free base)
AST-1306 is a novel irreversible inhibitor of EGFR and ErbB4 with IC50 of 0.5 nM and 0.8 nM, respectively. AST1306 was found to function as an ir...
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A 83-01
A83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 val...
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Golvatinib (E 7050)
Golvatinib (also known as E7050) is [1][2]an orally bioavailable dual kinase inhibitor of c-Met and VEGFR-2 tyrosine kinases with potential anti...
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GNF 2
GNF-2 is an allosteric inhibitor of Bcr-abl tyrosine kinase activity (IC50 = 267 nM) and inhibits proliferation and induces apoptosis in Bcr-abl-expre...
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NVP-AST 487 (AST 487)
AST 487, novel first-generation ‘type II’ FLT3 inhibitor, potently and selectively targets mutant FLT3 protein kinase activity and inhibit...
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Rebastinib (DCC 2036)
DCC-2036 is a conformational control inhibitor of Abl1 and T315I Abl1 with IC50 of 0.8 nM and 4 nM, respectively. DCC2036 binds to and inhibits t...
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Apatinib (YN968D1)
Apatinib (YN968D1) is a small-molecule selective multitargeted tyrosine kinase inhibitor with an IC50 of 2.43 nM for the inhibition of VEGFR2. Apatini...
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Ki 8751
Ki8751 is a potent and selective inhibitor to VEGFR-2 with IC50 of 0.9 nM. Ki-8751 displays some inhibitory activity towards c-Kit, PDGFRα and F...
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BMS 794833
BMS794833 is a potent ATP competitive inhibitor of Met and VEGFR2 with IC50 of 1.7 nM and 15 nM, respectively. BMS-794833 also inhibits Met receptor a...
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AMG 458
AMG458 is a Potent, Selective, and Orally Bioavailable c-Met Inhibitor with Ki=2.0, IC50(CT26)=120 nM significantly inhibited tumor growth in the NIH3...
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NVP-BVU972
NVP-BVU972 is a selective and potent MET kinase inhibitor with IC50 of 14 nM. NVP-BVU972 potently inhibits MET kinase but displays low inhibition agai...
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MK 2461
MK-2461 is a potent inhibitor of c-Met, Ron, Flt1, Flt 3, PDGFRβ, and Mer with IC50 of 2.5 nM, 7 nM, 10 nM, 22 nM, 22 nM and 24 nM, respectively....
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PF 04217903
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM. PF04217903 selectively binds to and inhibits c-Met, disrupting the c-M...
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WZ 3146
WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM, respectively. [1]
Re...
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Gefitinib
Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 ...
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