ARRY 380

ARRY-380 is an orally bioavailable, potent, selective, small-molecule tyrosine kinase HER2 inhibitor with an IC50 of 8 nM.ARRY380 selectively binds to...

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Mubritinib (TAK 165)

Mubritinib (TAK165) is a potent inhibitor to ErbB2 with IC50 of 6 nM. Mubritinib (TAK-165) displays > 4000-fold selectivity over other tyrosine kin...

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CP 724714

CP-724714 is a potent, selective inhibitor of erbB2 with IC50 of 10 nM. CP724714 is marked selectively against EGFR with IC50 of 6.4 μM. CP 724714 ...

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Nilotinib (AMN 107)

Nilotinib (AMN-107, Tasigna) is a Bcr-Abl inhibitor with IC50 less than 30 nM. Nilotinib (AMN107) binds to and stabilizes the inactive conformation of...

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AG 1024 (Tyrphostin)

AG-1024 (Tyrphostin) is a specific IGF-1R/IR inhibitor with IC50 of 0.4 μM and 0.1 μM, respectively. Human breast cancer cell studies report AG1...

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KX2-391 (KX 01)

KX2-391 (KX01) is a highly selective non-ATP Src kinase inhibitor that targets the substrate binding site of Src, and shows very potent antiproliferat...

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BGJ 398 (NVP-BGJ398)

BGJ398 (NVP-BGJ398) is a potent and selective fibroblast growth factor receptor family inhibitor for FGFR1, FGFR2, FGFR3 and FGFR4 with IC50 of 0.9 nM...

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XL 647 (EXEL 7647)

XL647 (EXEL-7647) is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major ...

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ABT-869 (Linifanib, AL 39324)

ABT-869 (Linifanib) is a novel, potent ATP-competitive RTK inhibitor of KDR, CSF-1R, Flt1 and Flt3 with IC50 of 4 nM, 3 nM, 3 nM and 3 nM, respectivel...

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AP 24534 (Ponatinib)

AP24534 (Ponatinib) is a novel, potent multi-targeted inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 ...

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AZD 8931 (Momelotinib)

AZD8931 (Momelotinib) is a reversible, ATP competitive inhibitor of EGFR, erbB2 and erbB3 with IC50 of 4 nM, 3 nM and 4 nM, respectively. AZD-8931 bin...

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GW 788388

GW788388 is a potent, selective, and orally inhibitor of ALK5 with IC50 of 18 nM. GW-788388 inhibits esophageal squamous cell carcinoma (ESCC)-induced...

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Pelitinib (EKB 569)

Pelitinib (EKB-569) is a potent EGFR tyrosine kinase inhibitor with IC50 of 38.5 nM. EKB569 irreversibly binds covalently to epidermal growth factor r...

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AEE 788

AEE788 (NVP-AEE788) is a novel multitargeted human epidermal receptor (HER) 1/2 and vascular endothelial growth factor receptor (VEGFR) 1/2 receptor f...

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SB 431542

SB-431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 ...

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PCI 32765

PCI-32765 (Ibrutinib) is a potent and highly selective Bruton's tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM. PCI32765 binds to and inhibits BT...

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