Etravirine (TMC-125) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), designed to be active against HIV with mutations t...

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HMN 214 (IVX 214)

HMN-214 (IVX-214) is an oral and potent inhibitor to Polo-like kinase (Plk)1 with IC50 of 118 nM. HMN-214 is an oral prodrug that is rapidly converted...

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LY 2603618 (IC 83)

LY2603618 (IC83) is a highly selective Chk 1 inhibitor with potential antitumor activity. LY-2603618 (IC-83) binds to and inhibits the activity of chk...

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Roscovitine (Seliciclib, CYC 202, R-roscovitine)

Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective inhibitor of the cyclin-dependent kinases with IC50 of 0.65, 0.7, 0.7 and 0....

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BS 181

BS-181 is a highly selective cyclin-dependent kinase (CDK) inhibitor of CDK7 activity with IC50 of 21 nM. CDK7, which also regulates transcription as ...

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CGP 60474

CGP60474 is a potent inhibitor of cyclin-dependent kinase (CDK). [1] Reference: [1] J Med. Chem. 2005, 48, 4536-4546. Chemi...

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PHA 793887

PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM, respectively. PHA793887 was also effective in viv...

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Dinaciclib (SCH 727965)

Dinaciclib (SCH727965) is a novel and potent cyclin-dependent kinase inhibitor for CDK2, CDK5, CDK1, and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, ...

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PHA 848125

PHA-848125 is a potent, ATP-competitive cyclin A/CDK2 inhibitor with an IC50 of 45 nM. PHA848125 potently inhibits cyclin-dependent kinase 2 (CDK2) an...

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R 547

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, ...

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AZD 5438

AZD5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 with IC50 of 16 nM, 6 nM, and 20 nM, respectively. AZD-5438 exhibits antipr...

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SNS 032 (BMS 387032)

SNS-032 (BMS387032) is a novel, potent and selective CDK inhibitor of CDK2, CDK7 and CDK9 with IC50 of 38 nM, 62 nM and 4 nM, respectively. CDK inhibi...

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Flavopiridol (HMR 1275, L 868275)

Flavopiridol (Alvocidib, HMR-1275, L-868275) is a pan-CDK inhibitor targeting CDK1, CDK2, CDK4, CDK5, CDK6, and CDK9 with IC50 of 30 nM, 170 nM, 100 n...

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ABT 751 (E7010)

ABT-751 (E7010) is a orally bioavailable tubulin-binding and antimitotic sulfonamide which binds to the colchicine site on ß-tubulin and inhibit...

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Kenpaullone

Kenpaullone is an ATP-competitive inhibitor of several CDKs (cyclin-dependent kinases) as well as GSK-3 (glycogen synthase kinase 3). It has been show...

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CYT 997

CYT997 is a novel anti-cancer vascular disrupting agent (VDA). In vitro, CYT-997 is shown to potently inhibit the proliferation of vascular endothelia...

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