NVP-TAE684 (TAE684)

TAE684 (NVP-TAE684) is a highly potent and selective smallmolecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell line...

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SB 525334

SB 525334 is a potent and selective inhibitor of the transforming growth factor-β1 (TGF-β1) receptor (activin receptor-like kinase 5, ALK5) ...

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CH 5424802

CH5424802 is a potent and selective ALK inhibitor with IC50 of 1.9 nM. Upon administration, ALK inhibitor CH-542480 binds to and inhibits ALK kinase, ...

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Masitinib (AB 1010)

AB1010 (Masitinib) is a tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor with IC50 of 150 ± 80, 200 ± 40 nM for KIT tyros...

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Dacomitinib (PF 299804)

PF299804 (Dacomitinib) is a potent, irreversible pan-ERBB inhibitor against EGFR (ERBB1), ERBB2 and ERBB4 with IC50 with 6 nM, 45.7 nM and 73.7 nM, re...

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PD 153035

PD-153035 is an extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal...

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Neratinib (HKI 272)

Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively. Neratinib binds to the HER-2 receptor ir...

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Lapatinib (Tykerb)

Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 nM and 9.2 nM, respectively.Lapatinib r...

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Afatinib (BIBW 2992)

BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFR L858R , EGFR L858R/T790M and HER2 with IC50 of 0.5 nM, 0.4...

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BMS 690514

BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kinases. BMS69...

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WZ 4002

WZ4002 is a novel, mutant-selective EGFR kinase inhibitor for EGFR L858R and EGFR L858R /T790M with IC50 of 2 nM and 8 nM, respectively. WZ-4002...

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WZ 8040

WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM). WZ-8040 is an irreversiblely inhibitor against EGFR T790M (mutation of the gatek...

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Saracatinib (AZD 0530)

Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kin...

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Danusertib (PHA 739358)

Danusertib (PHA-739358) is a pyrrolo-pyrazole and small molecule aurora kinases and Bcr-Abl kinase inhibitor for aurora A, B, and C with IC50 of 13 nM...

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Dasatinib (BMS-354825)

Dasatinib (BMS-354825, Sprycel) is a Src/Abl inhibitor for wild type Abl and Src with IC50 of 0.6 nM and 0.8 nM, respectively. Dasatinib binds to and ...

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Bosutinib (SKI 606)

Bosutinib (SKI-606) is a novel dual Sarcoma/Abelson (Src/Abl) tyrosine kinase inhibitor with IC50 values of 1.2 nM and 1 nM, respectively. Bosutinib (...

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