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R 406
R406 (free base) is a spleen tyrosine kinase (Syk) inhibitor with IC50 of 41 nM. R-406 is an ATP-competitive inhibitor of Syk with a Ki value of 30 nM...
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Brivanib alaninate (BMS-582664)
Brivanib alaninate (BMS-582664) is VEGFR-PDGFR inhibitor. Brivanib alaninate is a multiple inhibitor of VEGFR( IC50 of VEGFR-2(25 nM), VEGFR-1 (380nM)...
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Telatinib (BAY 57-9352)
Telatinib (BAY 57-9352) is a potent inhibitor of VEGFR-2, VEGFR-3, c-Kit and PGFR-β with IC50 of 6 nM, 4 nM, 1 nM and 15 nM, respectively. Telati...
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MGCD 265
MGCD-265 is a potent, multi-target, and ATP-competitive inhibitor of receptor tyrosine kinases, including Met, VEGFR, Ron, and Tie2, with IC50 of 1 nM...
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SU 11274
SU11274 is selective inhibitor of MET tyrosine kinase activity (IC50 = 10 nM in vitro). SU-11274 reduces cell growth in a dose-dependent manner; induc...
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PHA 665752
PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM. c-Met is highly expressed in most tumors from patients with a...
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SGX-523
SGX-523 is an exquisitely selective MET receptor tyrosine kinase inhibitor with an IC50 of 4 nM. SGX523 specifically binds to c-Met protein, or hepato...
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AMG 208
AMG-208 is a highly selective c-Met inhibitor with IC50 of 9.3 nM. AMG208 inhibits the ligand-dependent and ligand-independent activation of c-Met, in...
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JNJ-38877605
JNJ-38877605 is an ATP-competitive inhibitor for the catalytic activity of c-Met with IC50 of 4 nM. JNJ38877605 selectively binds to c-Met, thereby in...
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ARQ-197 (Tivantinib)
ARQ-197 (Tivantinib) is a novel and selective human c-Met receptor tyrosine kinase inhibitor with IC50 of 0.1 μM. ARQ197 binds to the c-Met protein...
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Crizotinib (PF 2341066)
PF-2341066 (Crizotinib) is a potent inhibitor for recombinant human c-Met kinase with Ki of 4 nM. Crizotinib, in an ATP-competitive manner, binds to a...
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AG 490 (Tyrphostin B42)
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2,...
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Foretinib (GSK 1363089, XL 880)
Foretinib (GSK1363089, XL880) is a novel MET and VEGFR2/KDR kinases inhibitor with an IC50 of 0.4 and 0.8 nM for MET and KDR, respectively. GSK-136308...
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Dovitinib (TKI-258)
Dovitinib (TKI258, CHIR258) is a novel multitargeted growth factor receptor kinase inhibitor of FLT3, c-KIT, FGFR1/3, VEGFR1/2/3 with IC50 of 1 nM, 2 ...
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Imatinib (Gleevec)
Imatinib Mesylate (Gleevec, CGP-51748B) is a multitargeted c-kit, PDGF-R and c-ABL inhibitor with IC50 of 3.9 and 2.9 μM for the inhibition of T-ce...
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