Bay 11-7082 (BAY 11-7821)

Bay 11-7082 (BAY 11-7821) inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM. The transcription factor NF-κB pla...

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Pifithrin-α

Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. It enhances cell survival after genotoxic ...

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Apoptosis Activator 2

Apoptosis activator 2, a cell permeable indoledion compound, promotes the cytochrome c-dependent oligomerizatioin of Apaf-1 into the mature apoptosome...

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Tenovin 1

Tenovin-1 is a p53 activator that protects against MDM-2 mediated degradation. Tenovin-1 has been shown to activate and elevate acetylated p53 levels,...

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RITA (NSC 652287)

MDM-2 is a key negative regulator of p53 that binds to and targets p53 for proteasomal degradation. Overexpression of MDM-2 in some tumors leads to in...

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NSC 207895 (XI 006)

NSC-207895 (XI-006) is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A5...

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Lonafarnib (SCH 66336)

Lonafarnib (SCH66336) is a selectively farnesyl protein transferase (FPT) inhibitor of H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 n...

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PAC-1

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM. Elevated caspase 3 level in cancer cell lines allows PAC1 to selectively induce apop...

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Navitoclax (ABT 263)

Navitoclax (ABT-263) is a novel small molecule dual Bcl-2/Bcl-xL inhibitor designed to restore apoptosis, also known as programmed cell death, by bloc...

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Obatoclax (GX15-070)

Obatoclax is an inhibitor of the Bcl-2 family of proteins with Ki of 0.22 μM. This inhibition induces apoptosis in cancer cells, preventing tumor g...

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HA 14-1

HA 14-1, Cell-permeable inhibitor of Bcl-2 protein (IC50 9 μM), acts by binding t the surface pocket. Disrupts Bax/Bcl-2 interaction and induces ap...

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ABT-737

ABT-737 is a cell-permeant pan-Bcl-2 inhibit that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and ...

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TW-37

TW-37 is Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11μM for Bcl-2 and Bcl-XL respectively). TW-37 inhibits the angiogenic potential of endoth...

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Nutlin-3a (chiral)

Nutlin-3 is a MDM-2 antagonist with an IC50 of 90nM. It is the compound most commonly used in anti-cancer studies. Inhibiting the interaction between ...

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Nutlin-3

Nutlin-3 is a MDM-2 antagonist with an IC50 of 90nM. It is the compound most commonly used in anti-cancer studies. Inhibiting the interaction between ...

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Serdemetan (JNJ 26854165)

Serdemetan (JNJ-26854165) is a novel tryptamine compound which activated p53 and acts as a HDM2 ubiquitin ligase antagonist. It inhibits cell growth a...

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