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GDC 0879
GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate ...
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SB 590885
SB 590885 is an orally bioavailable inhibitor of B-raf (BRAF) protein with a Ki app of 0.16 ± 0.03 nM. Dabrafenib selectively binds to and inhi...
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PD 0325901
PD 0325901 is an orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with a Ki ...
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GSK 1120212 (Trametinib, JPT 74)
GSK 1120212 (Tranmetinib) is a reversible, selective, allosteric MEK1/MEK2 kinase activity inhibitor with IC50 of 0.7 nM and 0.9 nM for MEK1 and MEK2....
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GDC 0973 (XL 518)
GDC 0973 is an orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplast...
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PD 98059
PD 98059 is a potent, selective and cell-permeable inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase). It inhibits phos...
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CI 1040 (PD 184352)
PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2 with a Ki of 300 nM in vitr...
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AS 703026 (AS703026)
MEK inhibitor AS703026 selectively binds to and inhibits the activity of MEK1/2 with IC50 value ranging from 2 nM to 20 μM, preventing the activati...
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BIX 02188
BIX02188 significantly blocked MEK5 catalytic activity with an IC50 value of 4.3 nM and inhibits ERK5 catalytic activity with an IC50 value of 0.83 &m...
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AZD 8330
AZD 8330 is an orally active, selective MEK inhibitor with IC50 of 7 nM. MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase ...
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PD 318088
PD 318088 is a non-ATP competitive allosteric MEK1/2 inhibitor. It is a small-molecule inhibitor bound within the allosteric site. The binding modes o...
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PLX 4720
PLX 4720, developed by Plexxikon, Inc., is a 7-azaindole derivative that inhibits B-Raf (V600E) with an IC50 of 13 nM, defines a class of kinase inhib...
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MEK 162
MEK 162 (ARRY-162) is an orally available inhibitor of MEK1 and MEK2 with potential antineoplastic activity. MEK 162, noncompetitive with ATP, binds t...
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