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SCH 1473759
SCH-1473759 is a novel sub-nanomolar Aurora A/B inhibitor. SCH1473759 was active against a large panel of tumor cell lines from different tissue origi...
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AZD 4877
AZD-4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. AZD4877 selectively inhibits microtubule motor...
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MK 5108 (VX 689)
MK-5108 (VX-689) is a highly selective Aurora-A kinase inhibitor with an IC50 of 0.064 nM. MK5108 (VX689) inhibited growth of human tumor cell lines i...
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PF 03814735
PF-03814735 is a novel, potent, orally bioavailable and reversible inhibitor of both Aurora1 and Aurora2 kinases with IC50 with 0.8 nM and 5 nM, respe...
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ARRY 520
ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest duri...
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AZ 3146
AZ-3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). AZ3146 displays selectivity over 46 other kinases includ...
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MPS-1-IN-1
MPS-1-IN-1 is a selective, potent small molecule inhibitor of Mps1. Mps1, a dual-specificity kinase, is required for the proper functioning of the spi...
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CCT 137690
CCT137690 is a highly selective Aurora kinases inhibitor to Aurora-A, Aurora-B and Aurora-C with IC50 of 15 nM, 25 nM and 19 nM, respectively. CCT-137...
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Barasertib (AZD1152-HQPA)
Barasertib (AZD1152-HQPA) is an orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase B inhi...
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ZM 447439
ZM-447439 is a potent and selective inhibitor of Aurora B kinase (IC50=50nM), Aurora A and C are inhibited at higher concentrations (IC50=1000nM and 2...
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VX 680
Tozasertib(VX 680, MK 0457)is a synthetic, small-molecule Aurora kinase A,Aurora kinase B, and Aurora kinase C inhibitor with IC50 value of 0.6, 18,4....
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PHA 680632
PHA-680632 is the first representative of a new class of Aurora inhibitors (Aurora A/B/C IC50 at 27, 135 and 120 nM, respectively). This agent has a h...
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MLN 8054
MLN 8054 is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential an...
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GSK 1070916
GSK1070916 is a novel ATP competitive inhibitor that is highly potent and selective for Aurora B/C kinases. Human tumor cells treated with GSK1070916 ...
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Hesperadin
Hesperadin is an ATP-competitive inhibitor of Aurora B kinase with IC50 of 250 nM. Hesperadin prevents chromosome alignment and segregation; also indu...
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