Acadesine

Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in tr...

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BX 795

BX795 is a potent and relatively specific TBK1 and IKKε inhibitor with IC50 of 6 nM and 41 nM. BX795 also suppresses MARK1, MARK2, MARK4, NUAK...

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GDC 0068

GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2, and Akt3 with IC50 of 5 nM, 18 nM, and 8 nM, respectively. GDC-0068 only inhibi...

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Triciribine

Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt phosphorylation and HIV-1 with IC50 with 130 nM and 20 nM, respectively. T...

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CH 5132799

CH5132799, a novel class I PI3K inhibitor, exhibits a strong inhibitory activity especially against PI3Kα with IC50 with 0.014 μM. CH-5132799...

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WYE 687

WYE-687 is a potent ATP-competitive mTOR inhibitor with an IC50 of 7 nM. WYE687 is well reported that the mammalian target of rapamycin (mTOR) is cent...

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PIK 293

PIK-293 is a PI3-K inhibitor. PIK293 inhibit the p110α, p110β, p110δ, and p110γ with IC50 of 100uM,25μM,0.24μM,and 10μ...

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AS 604850

AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM. AS604850 is ATP-competitive PI3Kγ inhibitor with Ki values ...

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PIK 294

PIK-294 is a highly potent and selective p110δ inhibitor with IC50 of 10 nM. PIK294 is a PI3 Kinase inhibitor that is 20- to 60-fold more potent...

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GSK 1059615

GSK1059615 is a novel and dual inhibitor of phosphoinositide 3-kinases (PI3Kα, β, δ, and γ) and mammalian target of rapamycin (...

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SB 415286

SB415286 is a potent GSK3α and GSK3β inhibitor with IC50 of 78 nM and ~78 nM, respectively. SB-415286 has minimal activity against 24 other...

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CHIR 98014

CHIR-98014 is a potent and selective human GSK-3 inhibitor for human GSK-3ɑ and human GSK-3β with IC50 of 0.65 nM and 0.58 nM, respectively. Eeff...

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AS 252424

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. AS252424 inhibits human recombinant PI3Kγ, α, β, an...

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PF 04691502

PF-04691502 is a potent and selective dual PI3K/mTOR inhibitor to phosphorylation of AKT T308 and AKT S473 with IC50 of 7.5 and 3.8 nM, respectively. ...

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A 769662

A-769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 μM) that displays selectivity towards β1 subunit-co...

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Compound 401

Compound 401 reversibly and selectively inhibits DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 ...

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