MLN 2238

MLN-2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM. MLN2238 has a greater...

More>>

MLN-9708 (Ixazomib)

MLN-9708 (Ixazomib) is a selective, orally bioavailable, second-generation proteasome inhibitor of chymotrypsin-like proteolytic (β5) site of the...

More>>

Bortezomib (PS 341, MG 341)

Bortezomib (PS-341, Velcade) is a potent proteasome inhibitor with Ki of 0.6 nM. The boron atom in bortezomib binds the catalytic site of the 26S prot...

More>>

Sitagliptin (MK 0431)

Sitagliptin phosphate (MK-0431) is a potent, orally active inhibitor of DPP-IV with an IC50 of 19 nM in Caco-2 cell extracts. [1][2] Ref...

More>>

Linagliptin (Synonyms: BI 1356)

Linagliptin (BI-2536) is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent in...

More>>

Saxagliptin (BMS 477118)

Saxagliptin (BMS-477118), is a new oral hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 50 nM. ...

More>>

PF 429242

PF-429242 is a cell permeable, reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 &m...

More>>

Nafamostat

Nafamostat mesylate is a broad spectrum serine protease inhibitor. It displays selectivity for human tryptase when used at relatively low concentratio...

More>>

Camostat

Camostat mesylate, a protease inhibitor, has been found to cause significant increase in the bicarbonate concentration, secretory rate, and output of ...

More>>

MPC 3100

MPC-3100 is a fully synthetic potent small-molecule Hsp90 inhibitor with IC50 of 60 nM. Hsp90 inhibitor MPC3100 selectively binds to Hsp90, thereby in...

More>>

MG 132

MG132 (carbobenzoxyl-leucyl-leucyl-leucinal, ZLLLal) is potent inhibitor of proteasome with IC50 of 100 nM. MG 132 potently inhibits TNF-α-induc...

More>>

Delanzomib (CEP 18770)

Delanzomib (CEP-18770) is a potent chymotrypsin-like proteasome inhibitor with an IC50 of 3.8 nM.Delanzomib (CEP18770) represses the proteasomal degra...

More>>

BMS 790052

BMS-790052 is a first-in-class, highly selective inhibitor of hepatitis C virus (HCV) NS5A with an EC50 of 9–50 pM. NS5A is an essential compone...

More>>

PF 04929113 (SNX 5422)

PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with Kd of 41 nM and also inhibits Her-2 degradation with IC50 of 37 nM. Although the...

More>>

UK 383367

UK 383367 is a novel, potent procollagen C-proteinase (PCP) inhibitor with an IC50 of 44 nM. In the fibroplasia model, UK-383367 inhibited deposition ...

More>>

Elesclomol (SAT 4783)

Elesclomol (STA4783) induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells ...

More>>

Total: 39 Page: 2 / 3 First ←Previous Next→ End