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BIBF1120
BIBF1120 (Vargatef) is a potent VEGF receptor (VEGFR), PDGFR and FGFR kinase inhibitor for VEGFR1, VEGFR2, VEGFR3 with IC50 of 34 nM, 5 nM and 5 nM, r...
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INCB 28060
INCB-28060 is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.INCB28060 exhibits picomolar enzymatic potency and is highl...
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LDN 193189
LDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM resp...
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BMS 599626 (AC 480)
BMS-599626 (AC-480) is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potent...
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AZD 4547
AZD-4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3 with IC50 of of 0.2 nM, 2.5 nM, and 1.8 nM, respectively. FGFR inhibito...
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CP 547632
CP-547632, was identified as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases with IC50 of 11 and 9 nM, respec...
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PF 573228
PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM). In whole-cell experiments, PF573228 reversibly increased t...
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TAK 285
TAK-285 is a novel dual HER2 and EGFR inhibitor with IC50 of 17 nM and 23 nM, respectively.TAK285 might have the potential in the treatment of brain m...
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PF 562271
PF-562271 is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 catalytic activity with IC50 of 1.5 nM and 14 nM,...
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PF 431396
PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Pr...
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AST1306(tosylate)
AST-6, a rationally designed novelanilinoquinazoline compound, inhibited enzymatic activitiesof wild type EGFR and ErbB2 as well as EGFR L858R/T790M r...
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ASP 3026
ASP3026 is A potent and selective ALK ( Anaplastic Lymphoma Kinase) inhibitor. It is more selective than Crizotinib in a kinase panel, and showed pote...
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GSK 1838705A
GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50 of 2.0 and 1.6 nM, respectively. GSK 1838705A...
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Axitinib (AG 013736)
Axitinib (AG-013736) is a multiple receptor kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-β and c-KIT with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3...
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Vandetanib (Zactima, ZD 6474)
Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM. Vandetanib selectively inhibits the tyrosine kinase activity of vascu...
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