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Crenolanib (CP 868596)
Crenolanib (CP-868596) is a highly selective and potent PDGFR-α inhibitor with IC50 of 0.9 and 1.8 nM against PDGFRα and PDGFRβ, resp...
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NVP-AEW541 (AEW 541)
NVP-AEW541 (AEW541) is a selective IGF-1R kinase inhibitor. In vitro, AEW-541 inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 µ...
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BMS 536924
BMS-535924 is a potent inhibitor of the IGF-1 receptor in vitro (IC50 = 100 nM).BMS536924 has been shown to inhibit the catalytic activityof IGF...
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Bafetinib (INNO 406)
Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor with IC50 of 5.8 nM and 19 nM, respectively.INNO 406 specifi...
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Linstinib (OSI 906)
OSI-906 (Linsitinib) is a selective inhibitor of IGF-IR and IR with IC50 of 35 nM and 75 nM, respectively.OSI906 selectively inhibits IGF-1R, which ma...
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GSK 1904529A
GSK1904529A is a selective inhibitor of IGF-IR and IR with IC50 of 27 nM and 25 nM, respectively.GSK-1904529A blocks receptor autophosphorylation and ...
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CUDC 101
CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.Because of its integrated histone de...
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Canertinib
Canertinib (CI-1033, PD-183805) is a potent tyrosine kinase inhibitor of EGFR and erbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.Canertinib binds ...
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Tandutinib (MLN518)
Tandutinib (MLN518, CT53518) is an ATP-competitive and highly selective inhibitor of FLT3, PDGFR and c-Kit with IC50 of 0.22 μM, 0.20 μM and 0.1...
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KW 2449
KW-2449 inhibits FLT3 and ABL kinases with IC50 of 6.6 nM and 14 nM, respectively.KW2449 showed the potent growth inhibitory effects on leukemia cells...
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Quizartinib (AC220)
AC220 (Quizartinib) is a potent and selective inhibitor of FLT3 with IC50 values of 1.1 nM and 4.2 nM for FLT3-ITD and FLT3-WT autophosphorylation, re...
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NVP-ADW742 (ADW 742)
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM. NVP-ADW742 exhibits a 6-fold greater selectivity for IGF-1R versus InsR with IC50 of 2.8 &m...
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BMS 754807
BMS-754807 inhibits the phosphorylation of IGF-1R (IC50 = 13nM) and the downstream targets Akt (IC50 = 22nM) and MAPK (IC50 = 13nM) in the IGF-Sal cel...
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CP-673451
CP-673451 is a potent inhibitor of platelet-derived growthfactor ß-receptor (PDGFR-ß) kinase- andPDGF-BB-stimulated autophosphorylation of...
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KRN 633
KRN 633 is an ATP-competitive inhibitor of VEGFR kinase, with IC50 values of 170 nM, 160 nM and 125 nM for VEGFR-1, VEGFR-2 and VEGFR-3, respect...
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